α-Synuclein Gene May Interact with Environmental Factors in Increasing Risk of Parkinson's Disease
Identifieur interne : 001970 ( Main/Exploration ); précédent : 001969; suivant : 001971α-Synuclein Gene May Interact with Environmental Factors in Increasing Risk of Parkinson's Disease
Auteurs : Nicole M. Gatto [États-Unis] ; Shannon L. Rhodes [États-Unis] ; Angelika D. Manthripragada [États-Unis] ; Jeff Bronstein [États-Unis] ; Myles Cockburn [États-Unis] ; Matt Farrer [Canada] ; Beate Ritz [États-Unis]Source :
- Neuroepidemiology [ 0251-5350 ] ; 2010.
Abstract
Although of great interest and suggested in prior reports, possible α-synuclein
We used a population-based approach to examine whether the risk of Parkinson's disease (PD) depended on the combined presence of
Similar to recent meta- and pooled analyses, our data suggest a lower PD risk in subjects who were either homozygous or heterozygous for the
Url:
DOI: 10.1159/000315157
PubMed: 20664293
PubMed Central: 2945263
Affiliations:
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Le document en format XML
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<series><title level="j">Neuroepidemiology</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Although of great interest and suggested in prior reports, possible α-synuclein <italic>(SNCA)</italic>
gene-environment interactions have not been well investigated in humans.</p>
</sec>
<sec><title>Methods</title>
<p>We used a population-based approach to examine whether the risk of Parkinson's disease (PD) depended on the combined presence of <italic>SNCA</italic>
variations and two important environmental factors, pesticide exposures and smoking.</p>
</sec>
<sec><title>Results/Conclusions</title>
<p>Similar to recent meta- and pooled analyses, our data suggest a lower PD risk in subjects who were either homozygous or heterozygous for the <italic>SNCA</italic>
REP1 259 genotype, and a higher risk in subjects who were either homozygous or heterozygous for the REP1 263 genotype, especially among subjects with an age of onset ≤68 years. More importantly, while analyses of interactions were limited by small cell sizes, risk due to <italic>SNCA</italic>
variations seemed to vary with pesticide exposure and smoking, especially in younger onset cases, suggesting an age-of-onset effect.</p>
</sec>
</div>
</front>
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<name sortKey="Manthripragada, Angelika D" sort="Manthripragada, Angelika D" uniqKey="Manthripragada A" first="Angelika D." last="Manthripragada">Angelika D. Manthripragada</name>
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<name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name>
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